Metabolic acidosis (MA) is a highly prevalent disorder in a significant proportion of the population, resulting from imbalance in blood pH homeostasis.The heart, being an organ Gouging Carbons with very low regenerative capacity and high metabolic activity, is vulnerable to chronic, although low-grade, MA.To systematically characterize the effect o
Is perfectionism associated with academic burnout through repetitive negative thinking?
Academic burnout is prevalent among university students, although understanding of what predicts burnout is limited.This study aimed to test the direct and indirect relationship between two dimensions of perfectionism (Perfectionistic Concerns and Perfectionistic Strivings) and the Cartoon Art three elements of Academic Burnout (Exhaustion, Inadequ
A spectrum of free software tools for processing the VCF variant call format: vcflib, bio-vcf, cyvcf2, hts-nim and slivar.
Since its introduction in 2011 the variant call format (VCF) has been widely adopted for processing DNA and RNA variants in practically all population studies-as well as in somatic and germline mutation studies.The VCF format can represent single nucleotide variants, multi-nucleotide variants, insertions and deletions, and simple structural variant
Myelin-reactive B cells exacerbate CD4+ T cell-driven CNS autoimmunity in an IL-23-dependent manner
Abstract B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis.IgH[MOG] mice possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein (MOG).Here, we show that upon immunization with the T cell-obligate autoantigen, MOG[35-55], IgH[MOG] mice develop rapid and exacerbated experimental autoimmune encephalom
Mid-Left Ventricular Ballooning Variant Takotsubo Syndrome Induced by Treadmill Exercise Stress Testing
Stress-induced cardiomyopathy, also known as takotsubo cardiomyopathy, presents similar to Motor Armature Refacing Stick a myocardial infarction after a physical or emotional stressor but without any evidence of obstructive coronary artery disease.Different patterns of myocardial involvement and several triggering events have been reported, but cla